@嘉绒wa 看来你没有因为自己测出M117就歪屁股

,你对骑士魁首说的关于尼泊尔古人的情况没错

Table 1. ACA dental samples investigated in this studyPeriod/site Dates No. samples Sample IDChokhopani 3,150–2,400 yBP 1 C1Mebrak 2,400–1,850 yBP 3 M63, M240, M344Samdzong 1,750–1,250 yBP 4 S10, S35, S40, S41
Interestingly, all reads from our ACA individuals match the derivedallele for the nonsynonymous EGLN1 SNP rs186996510 (SIAppendix, Table S2), including the oldest Chokhopani sample (C1).This derived allele, c.12G > C (p.Asp4Glu), is reported in high frequencyin Tibetans (0.64–0.85) (22, 37), but is rare in low-altitudeEast Asians (0.03 in 1KG phase 3 East Asians) and virtually absentoutside East Asia. Functional studies have implicated this allele asplaying a role in oxygen homeostasis under hypoxic conditions (37,39). In contrast, reads supporting derived alleles at the EPAS1 SNPswere found in two of the three later Samdzong individuals (S35 andS41), but not in the earlier Chokhopani (C1) or Mebrak (M63) individuals.This observation of shared adaptive alleles between ancientACA individuals and contemporary Tibetans is consistent with ourgenome sequence results suggesting that the ACA inhabitants areaffiliated with contemporary high-altitude East Asians. In addition,the contrasting pattern of alleles for the two genes leads us to speculatethat the EGLN1 and EPAS1 adaptive haplotypes rose to highfrequency at different time points in these ancient high-altitudepopulations, although more samples must be sequenced to accuratelyestimate allele frequency change across time.